ZABOTRIX-ABE®
Trivalent Botulinum Antitoxin Type A+B+E
Anti-botulism serum is a product derived from equine plasma hyperimmunized by antigens of different types of Clostridium botulinum. Botulism is a dangerous disease that occurs as a result of consuming contaminated food, wound contamination, or colonization of the intestines of infants by Clostridium botulinum.
This disease will quickly cause severe poisoning and death due to the effect of botulinum toxin on the nervous system. There are eight different serotypes (A-H) of this bacterium, but most cases of poisoning are caused by botulinum toxin types A, B, and E. This product is prepared in trivalent form.
Anti-botulism serum is supplied as a clear sterile solution in 10 ml vials in the form of trivalent type (A: 50000, B: 5000, E: 10000 IU/Vial) A+B+E for intramuscular or intravenous injection. Each vial of the product contains f(ab΄)2 fragments of botulinum antitoxin as the active ingredient.
Trivalent anti-botulinum serum is used to treat poisoning with various types of Clostridium botulinum toxins or to prevent poisoning. Treatment of botulinum disease with antitoxin should be started quickly and without delay. In cases where poisoning with a specific type is diagnosed, the corresponding monovalent serum is prescribed, but if this is impossible, trivalent serum should be prescribed.
Botulinum antitoxin is the only way to treat botulism. This product has the following important advantages:
- Effective and safe treatment of all types of botulism poisoning
- Fast and strong therapeutic effect
- High quality of the product at the level of international standards
Trivalent Botulinum Antitoxin Type A+B+E
ZABOTRIX-ABE®
Zabot® Anti-Botulism Serum, Antigens of Different Types of Clostridium Botulinum
Anti-Botulism Serum is supplied as a clear sterile solution in 10 ml vials in the form of trivalent type (A:50000, B:5000, E: 10000 IU/Vial) A+B+E for intramuscular or intravenous injection. Each vial of the product contains f(ab΄)2 fragments of botulinum antitoxin as the active ingredient.
Botulinum antitoxin is the only way to treat botulism.
This product has the following important advantages:
Effective and safe treatment of all types of botulism poisoning
Fast and strong therapeutic effect
High quality of the product at the level of international standards
Product specifications
Product name: Zabotrix®
Generic name: BOTULINUM ANTITOXIN
Drug class: Vaccines and biological drugs
Drug ingredients: Each vial contains f(ab’)2 fragments of botulinum antitoxin along with phenol as a preservative
Drug forms:
Trivalent: 5000 IU Type A Antitoxin + 500 IU Type B Antitoxin + 1000 IU Type E Antitoxin
Monovalent type A: 5000 IU Type A Antitoxin
Monovalent type B: 500 IU Type B Antitoxin
Monovalent type E: 1000 IU Type E Antitoxin
Mechanism of action :
Toxin neutralization: Antibodies in the antibody trap and specifically neutralize botulism toxins types A, B, and E in the bloodstream.
Binding prevention: This action prevents the binding and entry of neurotoxins into motor nerve endings, stopping the progression of paralysis.
Immunological elimination: Antibody-toxin complexes are cleared from the body by the immune system.
Indications:
Treatment and prevention of botulism in suspected or confirmed cases of botulism caused by toxin types A, B, and E
Zabotryx® is considered the standard and life-saving treatment for botulism toxin poisoning, and its rapid administration immediately after clinical diagnosis is essential to prevent irreversible neurological complications and death. Supportive therapy is also vital in parallel with the administration of this drug.
Storage conditions:
Store at refrigerator temperature (2 to 8 ° C). Protect from frostbite
How to use:
Treatment dose: 0.5 ml per kg of body weight is administered. Half of the dose is diluted in 100 ml of 0.9% normal saline and injected as a slow intravenous injection (at least 30 minutes) and the other half is injected intramuscularly. Subsequent doses may be prescribed according to the protocol and with the doctor’s advice.
Prevention: For people at risk and without symptoms, 20 ml is injected intramuscularly.
Precautions:
Use with extreme caution in case of a history of allergy to any of the components of the product or previous injection of animal serums.
Use with caution in patients with a personal or family history of atopy (asthma, eczema, drug allergy).
The patient should be monitored after the injection and resuscitation facilities and adrenaline should be available.
Use in pregnancy (category C) only if clearly needed and when the potential benefits outweigh the potential risks to the fetus.
Use with caution during lactation.
Side effects:
Immediate hypersensitivity reactions (anaphylactoid): Hypertension, urticaria, dyspnea. In severe cases, anaphylactic shock or Quincke’s edema may occur.
Delayed hypersensitivity reactions (serum sickness): Usually appear about 6 days after injection as fever, skin rash, urticaria, and arthralgia.