Trivalent Botulinum Type A+B+E Antitoxin, ZABOTRIX-ABE®
Trivalent Botulinum Type A+B+E Antitoxin
Trivalent Botulinum Antitoxin is a preparation containing antitoxic globulins that have the power of specifically neutralizing the toxins formed by clostridium botulinum type A, B and E. It is obtained by fractionation from the serum of horses, that have been hyperimmunized against Clostridium Botulinum type A, B and E toxoids. Botulism usually follows ingestion of contaminated preserved foodstuffs, but may develop from infected wounds or gastrointestinal colonization in infants. Eight types of Clostridium Botulinum (A-H) can be distinguished, human disease is usually caused by types A, B&E. ZABOTRIX-ABE® is prepared as a trivalent form. This botulinum immunosera is a sterile solution in 10 ml Single-use vials as a Trivalent Type A+B+E (A:50000, B:5000, E: 10000 IU/Vial) form for IM or IV administration. Trivalent Botulinum antitoxin is used in the postexposure prophylaxis and treatment of botulism. Treatment should be given as early as possible in the course of the disease. If the type of botulinum toxin known the related monovalent antitoxin should be used, but in the cases with unknown types of botulinum toxin trivalent antitoxin shall be administered. Since the types of botulinum toxin is seldom known the trivalent antitoxin is usually given. In patients that treatment started with polyvalent antitoxin, after recognition of toxin type treatment should be continued with related monovalent antitoxin.
The botulinum antitoxin is only specific treatment product for botulism diseases. This drug has numerus following advantages:
- • Safe and effective therapy for intoxications by different botulinum toxins.
- • Quick and potential clinical results.
- • High quality according to international standards.